Enhancing the delivery of carbon monoxide and oxygen
Carbon monoxide (CO) at very low doses acts as a messenger to cells decreasing inflammation, reducing oxygen requirements, and preventing programmed cell death (apoptosis). The MP4 molecule can be modified to carry CO and other gasses to enhance therapeutic benefit for certain patients . Preclinical studies have shown that CO at therapeutic, non-toxic therapeutic levels stabilizes the hemoglobin of patients with sickle cell disease and prevents the sickling of red blood cells. MP4CO is an ischemic rescue therapy for sickle cell crisis. It has been designed to improve perfusion and limit progression of the vaso-occlusive crisis associated with sickle cell disease, based on its anti-sickling, anti-inflammatory and anti-ischemic properties.Once the CO is released from the compound, the MP4 molecule is oxygenated in the lung and then delivers oxygen to the ischemic tissues.