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The MP4 gas-delivery platform is being used to develop ischemic rescue therapies. These are being developed for patients in crisis who are experiencing ischemia (oxygenation deprivation of tissues) and organ dysfunction as a result of hemorrhagic shock injury or a vaso-occlusive crisis associated with sickle cell disease.
The MP4 molecule is made using a chemical process called pegylation. In this process, polyethylene glycol (PEG) polymers are chemically attached to the surface of unmodified hemoglobin tetramers derived from human red blood cells. Due to water's strong affinity for the PEG polymer, water molecules effectively surround the pegylated hemoglobin creating a PEG and water layer around the hemoglobin. This layer improves the properties of the molecule, allowing it to carry oxygen and other gases to optimize oxygen delivery through the capillaries, at the tissue level.
MP4OX - Enhancing the delivery of oxygen
MP4OX is an ischemic rescue therapy. It has been developed to perfuse and oxygenate tissues at risk of injury due to ischemia and hypoxia in patients experiencing hemorrhagic shock.
MP4CO - Delivering therapeutic carbon monoxide and oxygen
MP4CO is an ischemic rescue therapy for sickle cell crisis. It has been designed to improve perfusion and limit progression of the vaso-occlusive crisis associated with sickle cell disease, based on its anti-sickling, anti-inflammatory and anti-ischemic properties.
Sangart has designed the MP4 gas-delivery platform to develop a range of ischemic rescue therapies.
Because of the critical role oxygen plays in the human body, MP4 has the potential to help patients with medical conditions that cause ischemia, including hemorrhagic shock and sickle cell disease.
Please click here for a short animation describing MP4OX's unique mechanism of action.